Allele/Variant

Myo1htm1b(KOMP)Wtsi

Species
Mus musculus
Symbol
Myo1htm1b(KOMP)Wtsi
Category
allele
Allele of gene
Myo1h
Transgenic Constructs
None
Synonyms
None
Description
The L1L2_Bact_P cassette was inserted at position 114457184 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of the targeted exon(s) at position 114458217. The critical exon(s) were thus flanked by loxP sites and subsequent Cre-mediated excision deleted the neomycin selection cassette yielding a knockout reporter allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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