Allele/Variant

Adgra1tm1b(EUCOMM)Hmgu

Species
Mus musculus
Symbol
Adgra1tm1b(EUCOMM)Hmgu
Category
allele
Allele of gene
Adgra1
Transgenic Constructs
None
Synonyms
None
Description
The L1L2_Bact_P cassette was inserted at position 139431338 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of the targeted exon(s) at position 139432804. The critical exon(s) were thus flanked by loxP sites and subsequent Cre-mediated excision deleted the critical sequence and the neomycin selection cassette yielding this knockout reporter allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
improved glucose toleranceMGI
increased bone mineral contentMGI
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Disease Associations

No data available