Allele/Variant

Tardbptm1.1Jrob

Species
Mus musculus
Symbol
Tardbptm1.1Jrob
Category
allele
Allele of gene
Tardbp
Transgenic Constructs
None
Synonyms
  • Taradbp2lox
Description
BAC recombineering was used to insert a loxP site upstream of exon 2 and a neomycin resistance cassette flanked by FRT sites downstream of exon 3 followed by another loxP site. The neomycin selection cassette was removed via FLP-mediated recombination by breeding with Tg(ACTFLPe)9205Dym expressing mice, leaving exons 2 and 3 flanked by loxP sites. mRNA and protein expression of the adjacent Masp2 gene (in which the 2 last exons of Masp2 overlap with the 3' untranslated region) is reduced by about 50% in heterozygotes. Western blot analysis confirmed Taradbp protein expression in the brain, spinal cord, and liver tissue.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
embryonic lethality prior to organogenesis, complete penetranceMGI
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Disease Associations

No data available