Allele/Variant

Tg(Prnp-lacZ/ATXN10*)#Teas

Species
Mus musculus
Symbol
Tg(Prnp-lacZ/ATXN10*)#Teas
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
This transgene consists of the rat prion promoter, lacZ reporter gene, and 500 ATTCT repeats of human ATXN10 (isolated from a Mexican patient with ataxia and epilepsy) inserted in the 3' UTR of lacZ. RT-PCR analysis shows that the transgene is widely expressed in the central nervous system, with highest expression in the hippocampus, and also in the heart, liver, muscle, and skin. Three founders (1,2, 3) were established, however the pound symbol (#) is used when line is not specified and/or lines are pooled.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations