Allele/Variant

Tg(H2-Kb-Tcra,-Tcrb)1640Kurs

Species
Mus musculus
Symbol
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • RR mouse
  • TCR1640
Description
This transgene consists of a T-cell antigen receptor (TCR) that recognizes rat/mouse MOG peptide 92-106 bound to I-AS under the control of the MHC class I H2-Kb promoter. The TCR uses Valpha8.3 and Vbeta4 genes derived from a MOG-specific encephalitogenic Th1-CD4+ T cell clone isolated from a wild-type SJL/J mouse immunized against recombinant rat Mog. Three founder lines were established, differing in distinct proportions of transgenic Valpha8.3+/Vbeta4+ CD4+ T cells in central and peripheral immune repertoires. In the high frequency line 1640, 99% of single-positive CD4+CD8- thymocytes express the transgenic TCR.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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