Allele/Variant

Abcc9tm1.1Mcn

Species
Mus musculus
Symbol
Abcc9tm1.1Mcn
Category
allele
Allele of gene
Abcc9
Transgenic Constructs
None
Synonyms
None
Description
LoxP sites and a neomycin selection cassette were inserted into the flanking regions of exon 5. Mice heterozygous for the targeted allele were crossed with protamine-Cre transgenic mice to remove the neomycin cassette and exon 5. Deletion of exon 5 induced a frameshift and disrupted expression of the encoded protein. Expression of both the long form and the short form of the encoded protein was affected.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations