Allele/Variant

Atp2a2tm1.1Raco

Species
Mus musculus
Symbol
Atp2a2tm1.1Raco
Category
allele
Allele of gene
Atp2a2
Transgenic Constructs
None
Synonyms
  • SERCA 2 C674S
  • SKI
Description
A mutated exon 14 with a TGT to TCC mutation resulting in a Cys674Ser substitution and an FRT flanked neo cassette in intron 14 were inserted via homologous recombination. Flp mediated recombination removed the neo cassette. This mutation removes half of the key thiol that is a target of ischemia induced S-glutathiolation. The presence of the C674S allele was confirmed by sequencing of both genomic DNA and cDNA from cardiac endothelial cells.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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