Version: 8.0.0
Date: Tue Jan 28 2025
Isl1tm4Sev
MGI:5691395
Allele of Isl1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Isl1tm4Sev

Species
Mus musculus
Symbol
Isl1tm4Sev
Category
allele
Allele of gene
Isl1
Transgenic Constructs
None
Synonyms
  • Isl1 hypo
  • Isl1fl:Neo
Description
Exon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. This allele was used to generate Isl1tm2Sev and Isl1tm2.1Sev. Immunohistochemistry confirmed reduced protein expression in the spinal cord.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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