Ntn5^tm1.1Rwb

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Species

Mus musculus

Symbol

Ntn5^tm1.1Rwb

Category

allele

Allele of gene

Ntn5

Transgenic Constructs

None

Synonyms

None

Description

Exons 2-6 were replaced with a cassette encoding a farnysylated YFP fused to the 5-prime sequence of exon2 and an FRT-flanked neomycin resistance cassette, and subsequent flpe-mediated excision deleted the neomycin selection cassette. Although sequencing confirmed that the integrated YFPF is in-frame with the start site, no expression was detected by either endogenous fluorescence or antibody staining. Although this deletion is also in intron 1 of Sec1, Q-RT-PCR did not detect any reduction in Sec1 expression.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations