Allele/Variant

Tg(tetO-EGFR*T790M)8Paow

Species
Mus musculus
Symbol
Tg(tetO-EGFR*T790M)8Paow
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • EGFRT790M
  • line 8
Description
A mutant human epidermal factor receptor cDNA with a C-to-T nucleotide substitution in exon 20 that replaces threonine with methionine at amino acid position 790 (T790M) was cloned between a tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under control of a tissue-specific promoter can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. Five lines were established (8, 22, 37, 45, and 71) and line 8 is entered as a representative line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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