Allele/Variant

Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan

Species
Mus musculus
Symbol
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Cav2.2KD
  • Tg(Itgam-cre/ERT2,RNU6-RNAi:Cacna1b)17Ttan
Description
The transgene is composed of the human RNU6 promoter disrupted by a floxed neomycin resistance cassette, short-hairpin RNA targeting Cacna1b, the human GH sequence, and the mouse Itgam promoter driving expression of an inducible cre recombinase gene (cre/ERT2) in microglial/macrophage cells. Five founders were generated and line 17 was selected as the representative line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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