Samd8^tm2.1Kwi

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Species

Mus musculus

Symbol

Samd8^tm2.1Kwi

Category

allele

Allele of gene

Samd8

Transgenic Constructs

None

Synonyms

• SMSrflox

Description

The modified gene contains a loxP site upstream of exon 5, a single frt site (left by FLP recombinase excision of a neomycin resistance cassette) followed by a second loxP site downstream of the 3' UTR, and a second copy of exon 5 followed in-frame by the EGFP coding sequence. Cre recombinase-mediated excision of the endogenous exon 5 through the 3' untranslated region will result in splicing of exon 4 to the downstream copy of exon 5, leading to production of a SAMD8/EGFP fusion protein lacking the catalytic domain encoded by exon 6.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations