Samd8^tm2.2Kwi

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Species

Mus musculus

Symbol

Samd8^tm2.2Kwi

Category

allele

Allele of gene

Samd8

Transgenic Constructs

None

Synonyms

• SMSrdelEx6

Description

This allele is derived from Samd8^tm2Kwi or Samd8^tm2.1Kwi by Cre recombinase-mediated excision of the loxP-flanked segment that contained the endogenous exon 5 through the 3' untranslated region. It contains a single loxP site upstream of a second copy of exon 5, which is followed in-frame by the EGFP coding sequence. Processing of the primary transcript results in splicing of exon 4 to the downstream copy of exon 5, leading to production of a SAMD8/EGFP fusion protein lacking the catalytic domain encoded by exon 6.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations