Allele/Variant

Tg(Prnp-MAPT*K274Q*K281Q)286Lgn

Species
Mus musculus
Symbol
Tg(Prnp-MAPT*K274Q*K281Q)286Lgn
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • tauKQhigh
  • Tg(Prnp-MAPT*K274/281Q)2
Description
The transgenic construct contains a mutant human MAPT (tauKQ) transgene with lysine-to-glutamine amino acid substitutions that recapitulate MAPT K274 and K281 acetylation under the control of the mouse prion protein, Prnp, gene promoter. The nucleotide substitutions are, respectively, A to C at position 820 and A to C at position 841. Founder line 286 has higher expression of the transgene than founder line 1. The transgene is expressed in hippocampus, cortex and cerebellum.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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