Version: 8.0.0
Date: Tue Jan 28 2025
Lrrk2tm1.1Hlme
MGI:5750894
Allele of Lrrk2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Lrrk2tm1.1Hlme

Species
Mus musculus
Symbol
Lrrk2tm1.1Hlme
Category
allele
Allele of gene
Lrrk2
Transgenic Constructs
None
Synonyms
  • G2019S KI
Description
Exon 41 was replaced with a modified exon 41 with nucleotide substitutions (GGG to AGC) that results in the substitution of serine for glycine at position 2019 (G2019S). A floxed neomycin cassette was placed immediately downstream of exon 41 and was removed via cre-mediated recombination. Kinase activity is increased about 1.8-fold in heterozygotes and about 4-fold in homozygotes.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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