Allele/Variant

Htra2tm1.2Hohj

Species
Mus musculus
Symbol
Htra2tm1.2Hohj
Category
allele
Allele of gene
Htra2
Transgenic Constructs
None
Synonyms
  • HTRA2 KO
Description
A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 4. Western blotting confirmed loss of protein in brain, spleen, and thymus tissues from homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations