Version: 8.0.0
Date: Tue Jan 28 2025
Crppaem2Mbp
MGI:5776276
Allele of Crppa
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Crppaem2Mbp

Species
Mus musculus
Symbol
Crppaem2Mbp
Category
allele
Allele of gene
Crppa
Transgenic Constructs
None
Synonyms
  • Ispd floxed
  • Ispdem2Mbp
Description
A conditional allele in which the second of the gene's 10 exons is flanked by loxP sites was generated using a variation of CRISPR/Ca9 technology employing paired Cas9 nickase (Cas9n) RNA with associated sgRNAs and a single DNA template containing loxP sites flanking exon 2. Cre recombinase treatment of genomic DNA from an F1 pup inheriting the PCR-verified mutation demonstrated correct excision of exon 2.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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