Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Camk2a-Grin2b/Grin2a)1Jzt
MGI:5780186Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Camk2a-Grin2b/Grin2a)1Jzt

Species
Mus musculus
Symbol
Tg(Camk2a-Grin2b/Grin2a)1Jzt
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • GluN2B2A(CTR)
  • Tg-GluN2B2A(CT)
Description
The transgene is designed to have ~8.5 kbp of the mouse Camk2a promoter sequences placed upstream of a chimeric NMDA glutamate receptor followed by an SV40 polyadenylation signal. Specifically, the N-terminal and transmembrane domain sequences from the rat Grin2b locus are fused with the C-terminal intracellular domain sequences from the rat Grin2a locus. Mice from the founder line with the highest expression in forebrain regions (cortex and hippocampus) were propagated. The investigator reports that Southern blots indicate only one copy of the transgene was integrated into the genome, and there is no evidence of multiple copies.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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