Allele/Variant

Tg(tetO-MAPT*A152T)L1Lms

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

hTau-A152T
TRE-hTau-A152T

Description

A transgenic construct containing cDNA of the human MAPT gene encoding the 1N4R isoform, with upstream intronic sequence (from pCI-neo vector) and a Kozak sequence, and downstream bovine growth hormone polyadenylation sequence, all under the control of the tetO, a tetracycline-responsive regulatory element (pTRE-Tight). The 1N4R isoform of human MAPT (microtubule-associated protein tau) contains an A152T substitution, converting GCC (Ala) at positions 454-456 to ACC (Thr). Founder line C11-1, also known as founder line L1, was established.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

MAPT (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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