Allele/Variant

Tg(SFTPC-EGFR*L858R)4-3Kkiu

Species
Mus musculus
Symbol
Tg(SFTPC-EGFR*L858R)4-3Kkiu
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
The full-length human cDNA with a T to G mutation at nucleotide 2573 resulting in the substitution of arginine for leucine at codon 858 and also tagged at the COOH-terminal end with FLAG is under the control of the human type II alveolar epithelial cell specific surfactant protein-C promoter. RT-PCR from hemizygous mice shows an approximate 1.5- to 3-fold greater expression of the transgene compared with endogenous Egfr. Western blot confirmed restricted expression to lung tissue.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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