Allele/Variant

Arhgap35m1Bchd

Species
Mus musculus
Symbol
Arhgap35m1Bchd
Category
allele
Allele of gene
Arhgap35
Transgenic Constructs
None
Synonyms
  • Arhgap35D34
Description
ENU mutagenesis induced an A to T nucleotide exchange that alters amino acid leucine 1396 to glutamine in the C-terminal RhoGAP domain. The L1396Q substitution is a loss-of-function mutation that results in decreased GTPase-activating protein (GAP) activity for the prototypical Rho family members, RhoA and Rac1, likely due to disrupted ordering of the Rho binding surface.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

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    Disease Associations

    Association
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