Tubb2a^em1(IMPC)J

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Species

Mus musculus

Symbol

Tubb2a^em1(IMPC)J

Category

allele

Allele of gene

Tubb2a

Transgenic Constructs

None

Synonyms

• Tubb2a^em1J

Description

This allele from project Tubb2a-7712J-F7081 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences TTCCTTGTCTGCATGCTGGT, CTGCTTTCTCTGTCACGGTA, CTGTCACCAGAAAGACAGCA and AGAGATTCTAAGCATGATGT, which resulted in a 170 bp deletion beginning at Chromosome 13 negative strand position 34,076,680 bp ATGTGGGATTGTCTTCATTT, and ending after GTCTCGCTTTCCATACCGTG at 34,076,511 bp (GRCm38/mm10). This mutation deletes exon 2 and 61 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 19 and early truncation 9 amino acids later.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations