Version: 8.0.0
Date: Tue Jan 28 2025
Tg(PDGFB-LRRK2*R1441C)31Hlw
MGI:5800408Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(PDGFB-LRRK2*R1441C)31Hlw

Species
Mus musculus
Symbol
Tg(PDGFB-LRRK2*R1441C)31Hlw
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • (R1441C) LRRK2
Description
Human LRRK2 with the disease causing R1441C mutation with an HA tag on the C-terminus is under the control of the CMV enhancer/platelet-derived growth factor-beta chain promoter. Immunoblot analysis confirmed transgene expression in various brain regions, including the cerebral cortex, substantia nigra, and striatum. Western blot analysis indicates a 2-fold overexpression of the protein compared to the endogenous level in the substantia nigra. Two lines, 31 and 39, were established and line 31 is entered as the representative line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page