Allele/Variant

Lancl1em1Vdd

Species
Mus musculus
Symbol
Lancl1em1Vdd
Category
allele
Allele of gene
Lancl1
Transgenic Constructs
None
Synonyms
None
Description
Pronuclear-stage embryos were targeted with a zinc finger nuclease pair designed to target exon 3. A founder mouse was identified carrying a 19-bp deletion at the targeted site (CTCGGGatggcactgggtacactggCTGGGCAG -> CTCGGGCTGGGCAG), which causes a reading frame shift resulting in a premature stop codon. Absence of the protein in brain, heart and liver of homozygous mutant mice was confirmed by immunoblot analysis.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations