Allele/Variant

Polr1atm1b(EUCOMM)Hmgu

Species
Mus musculus
Symbol
Polr1atm1b(EUCOMM)Hmgu
Category
allele
Allele of gene
Polr1a
Transgenic Constructs
None
Synonyms
  • Polr1a-
Description
Cre-mediated excision of the parental Polr1atm1a(EUCOMM)Hmgu allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal preimplantation embryo developmentMGI
abnormal retina outer nuclear layer morphologyMGI
embryonic growth arrestMGI
embryonic lethality before implantation, complete penetranceMGI
failure of blastocyst formationMGI
preweaning lethality, complete penetranceMGI
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Disease Associations

No data available