Prdx6^tm2Abf

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Species

Mus musculus

Symbol

Prdx6^tm2Abf

Category

allele

Allele of gene

Prdx6

Transgenic Constructs

None

Synonyms

• Prdx6 S32T

Description

The targeting vector is designed to insert, by site-directed mutagenesis, a T(CG) to A(CG) point mutation followed by a FRT-flanked neomycin cassette 290 bp downstream of exon 1. The mutation results in an alteration of the corresponding amino acid from serine to threonine (S32T) at codon 32. The mutation does not affect phospholipase A2 activity, but does result in impaired trafficking of PRDX6 to the into lamellar bodies and lysosomes of the lung epithelium.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations