Allele/Variant

Gpd1lem1(IMPC)J

Species
Mus musculus
Symbol
Gpd1lem1(IMPC)J
Category
allele
Allele of gene
Gpd1l
Transgenic Constructs
None
Synonyms
  • Gpd1lem1J
Description
This allele from project Gpd1l-8296J-M9231 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences AGAAAGTCAGAGCCAGCCAA, TTGAGTGGCACCAGGACCTG, GGACTTGTGCGGGCTCCGAA and TATAAGAACAGAGTTTTCAG, which resulted in a 356 bp deletion beginning at Chromosome 9 negative strand position 114,920,771 bp, CGAATGGAAGTGCGAGACTT, and ending after AAGCAACCTTTGGCTGGCTC at 114,920,416 bp (GRCm38/mm10). This mutation deletes exon 2 and 178 bp of flanking intronic sequence including the splice acceptor and donor. There is an additional 9 bp deletion (AGTTTTCAG) 48 bp before the 356 bp deletion that will not alter the results of the larger deletion. This mutation is predicted to cause a change of amino acid sequence after residue 16 and early truncation 48 amino acids later.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations