Allele/Variant

Smc5tm1c(KOMP)Wtsi

Species
Mus musculus
Symbol
Smc5tm1c(KOMP)Wtsi
Category
allele
Allele of gene
Smc5
Transgenic Constructs
None
Synonyms
  • Smc5flox
Description
The L1L2_Bact_P cassette was inserted at position 23240733 of Chromosome 19 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 23241614. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations