Smc5^{tm1d(KOMP)Wtsi}

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Species

Mus musculus

Symbol

Smc5^{tm1d(KOMP)Wtsi}

Category

allele

Allele of gene

Smc5

Transgenic Constructs

None

Synonyms

• Smc5^del

Description

The L1L2_Bact_P cassette was inserted at position 23240733 of Chromosome 19 upstream of exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4 at position 23241614. Exon 4 is thus flanked by loxP sites. A null/knockout allele was created by flp- and cre-mediated recombination to remove the lacZ sequence, neo cassette and the floxed exon 4.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations