Itgb3bp^em1(IMPC)J

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Species

Mus musculus

Symbol

Itgb3bp^em1(IMPC)J

Category

allele

Allele of gene

Itgb3bp

Transgenic Constructs

None

Synonyms

• Itgb3bp^em1J

Description

This allele from project Itgb3bp-8308J-F0692 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences ATATAGCTCTTGTTGCAGCT, TTATAATTGATAGTAGCTGA, AAGTAGCTACCTTATTTGAG and GAGTTTTCATGAGTTACTTA, which resulted in a 2 part deletion of 558 bp in total. This deletion begins at Chromosome 4 negative strand position 99,802,399 bp TTTGAGAGGAATACTGGTCA, removes 222 bp then retains 4 endogenous exonic bases (CTAC) and ends after TATGGCCTGACTGCCTTCAG at 99,801,838 bp (GRCm38/mm10). This mutation deletes 132 bp in exon 3 and 426 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 17 and early truncation 7 amino acids later.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations