Podxl2^{tm1c(EUCOMM)Wtsi}

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Species

Mus musculus

Symbol

Podxl2^{tm1c(EUCOMM)Wtsi}

Category

allele

Allele of gene

Podxl2

Transgenic Constructs

None

Synonyms

• EG^flox
• Podxl2^flox

Description

The L1L2_Bact_P cassette was inserted at position 88825445 of Chromosome 6 upstream of the critical exons 3 and 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons at position 88827396. The critical exons 3 and 4 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking exons 3 and 4.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations