Mcmdc2^{tm4c(EUCOMM)Hmgu}

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Species

Mus musculus

Symbol

Mcmdc2^{tm4c(EUCOMM)Hmgu}

Category

allele

Allele of gene

Mcmdc2

Transgenic Constructs

None

Synonyms

• Mcmdc2^restored

Description

The L1L2_Bact_P cassette was inserted at position 9984471 of Chromosome 1 upstream of exon 5 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 7 at position 9987378. Exons 5-7 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exons 5-7.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations