Fan1^tm1.1Jrou

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Species

Mus musculus

Symbol

Fan1^tm1.1Jrou

Category

allele

Allele of gene

Fan1

Transgenic Constructs

None

Synonyms

• Fan1 nuclease defective
• Fan1^nd

Description

Exon 13 of the gene was replaced with a mutated exon where the codon for Lys975 was mutated to encode an alanine. An FRT-flanked puromycin resistance cassette was inserted adjacent to the mutation. Flp-mediated recombination removed the puromycin cassette and left a single FRT site between exon 13 and 14. This allele produces a truncated protein lacking the last 41 amino acids that is devoid of nuclease activity.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations