Allele/Variant

Tg(CAG-Ppard*E411P)#Als

Species
Mus musculus
Symbol
Tg(CAG-Ppard*E411P)#Als
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • PpardE411P
Description
This transgene consists of a combined beta-actin promoter-cytomegalovirus enhancer, a STOP cassette flanked by loxP sites and the mouse Ppard cDNA with a single amino acid mutation, a substitution of proline for glutamate at residue 411 (E411P). Cre-mediated recombination can be used to remove the STOP cassette and express the mutant protein. This mutation inhibits Ppard transactivation in a dominant-negative manner.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal basal ganglion morphologyMGI
abnormal cerebral cortex morphologyMGI
abnormal medium spiny neuron morphologyMGI
abnormal mitochondrial ATP synthesis coupled electron transportMGI
abnormal motor capabilities/coordination/movementMGI
abnormal response to novel objectMGI
decreased body weightMGI
decreased brain sizeMGI
decreased dopaminergic neuron numberMGI
decreased exploration in new environmentMGI
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Disease Associations