Babam2^{tm1b(EUCOMM)Wtsi}

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Species

Mus musculus

Symbol

Babam2^{tm1b(EUCOMM)Wtsi}

Category

allele

Allele of gene

Babam2

Transgenic Constructs

None

Synonyms

None

Description

The L1L2_gt2 cassette was inserted at position 31887866 of Chromosome 5 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 31888629. The critical exon 3 is thus flanked by loxP sites. Cre expression without flp expression creates a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. Western blot analysis and immunofluorescence confirmed the absence of protein expression in fibroblasts.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations