Allele/Variant

Cul3tm1Suc

Species
Mus musculus
Symbol
Cul3tm1Suc
Category
allele
Allele of gene
Cul3
Transgenic Constructs
None
Synonyms
  • Cul3G(-1)A
Description
A mutation in the C terminus of intron 8, c.1207-1G>A, was knocked into the locus along with a floxed neo cassette after exon 9 that was subsequently removed via cre-mediated recombination. This is one of the reported Pseudohypoaldosteronism type II-causing mutations in this gene in humans. RT-PCR and Western blot analysis indicate absence of any truncated forms which would be expected with loss of exon 9 during splicing, indicating a knock-out allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations