Allele/Variant

Pou4f3tm1.1(HBEGF)Rubel

Species
Mus musculus
Symbol
Pou4f3tm1.1(HBEGF)Rubel
Category
allele
Allele of gene
Pou4f3
Transgenic Constructs
Synonyms
  • Pou4f3DTR
Description
The human gene was inserted upstream of the translation start site and downstream of the promoter of the mouse host gene. The loxP site flanked neomycin resistance gene that was also inserted, was deleted through cre-mediated recombination. This leaves an allele with the Diphtheria Toxin sensitive human gene under control of the mouse promoter, rendering the cells where this allele is expressed sensitive to DT-induced cell death.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations