Allele/Variant

Tg(Myh6-Mybpc3*)24Rbns

Species
Mus musculus
Symbol
Tg(Myh6-Mybpc3*)24Rbns
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • MyBP-C.mut2
Description
The mouse cardiac truncated protein lacking the myosin protein binding domain (missing the 240 nucleotides at the 3' end) is under the control of the mouse alpha-myosin heavy chain promoter. The human myc epitope is placed after the initiator methionine residue. Western blot analysis indicates very little truncated protein in hearts while endogenous levels of Mybpc3 are unaffected. Multiple lines were established including 19, 24, and 133. All lines exhibit similar phenotypes and line 24 is entered as a representative line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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