Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Myh7-Ptpn11*Q510E)#Krnz
MGI:5909085Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Myh7-Ptpn11*Q510E)#Krnz

Species
Mus musculus
Symbol
Tg(Myh7-Ptpn11*Q510E)#Krnz
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
The murine beta-myosin heavy chain promoter drives the expression of a Ptpn11 cDNA which contains the amino acid substitution of glutamate for glutamine at position 510 (Q510E). Q510E is a dominant-negative loss-of-function mutation. The beta-myosin heavy chain promoter drives transgene expression starting around E11 and the transgene is expressed stably and continuously after birth. Several lines were generated including: 1, 3, 5, and 6, however, the pound symbol (#) is used when line is not specified and/or lines are pooled.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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