Tg(Myh6/tetO-Mybpc3*)#Rbns

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Species

Mus musculus

Symbol

Tg(Myh6/tetO-Mybpc3*)#Rbns

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

None

Description

This transgene contains a 40-kDa N-terminal fragment of Mybpc3 (amino acids 1-271, containing the C0 domain, a Pro/Ala-rich region, the C1 domain, and 17 residues of the M domain) under the transcriptional control of a mouse alpha-myosin heavy chain promoter fused to the tetracycline-response element (tetO). An N-terminal c-myc tag encoding the human c-myc peptide was inserted after the initiation methionine codon to differentiate transgenic protein from the endogenous one. Some leakage in the expression of the 40-kDa fragment is seen. Multiple lines were generated, however the pound (#) symbol is used because line number is not specified.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations