Allele/Variant

Mettl3tm1Jhha

Species
Mus musculus
Symbol
Mettl3tm1Jhha
Category
allele
Allele of gene
Mettl3
Transgenic Constructs
None
Synonyms
None
Description
KOMP vector PG00144_Z_5_D09 inserted at position 52299195 of Chromosome 14 upstream of the critical exon 4 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 52298473. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
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