Version: 8.0.0
Date: Tue Jan 28 2025
Tet1tm1Koh
MGI:5911919
Allele of Tet1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tet1tm1Koh

Species
Mus musculus
Symbol
Tet1tm1Koh
Category
allele
Allele of gene
Tet1
Transgenic Constructs
None
Synonyms
  • Tet1lacZ
Description
A target vector was designed to insert an “fl-NLS-lacZ-fl-mCherry-FRT-neo-FRT” cassette (containing ATG start codon and nuclear localization signal sequence 5’ of lacZ reporter gene with 3’ BGH polyA, flanked by 2 LoxP sites to allow reporter exchange to a downstream ATG-mCherry-pA cassette by Cre recombination, followed by a FRT-flanked neomycin selection cassette) in-frame at the ATG start codon in exon 2 of the gene Tet1. The targeting construct was electroporated into C57BL/6 mouse embryonic stem (ES) cells and selected in G418. The transgenic KI mouse strain was created by blastocyst injection of one correctly targeted clone. The strain has been bred to Flp-deleter mice to remove the neo cassette, resulting in one remaining FRT site downstream of the fl-NLS-lacZ-fl-mCherry cassette. The final modification is designated as Tet1-fl-lacZ-fl-mCherry.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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