Dot1l^{tm1c(KOMP)Wtsi}

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Species

Mus musculus

Symbol

Dot1l^{tm1c(KOMP)Wtsi}

Category

allele

Allele of gene

Dot1l

Transgenic Constructs

None

Synonyms

• Dot1l^fl

Description

The L1L2_gtk cassette was inserted at position 80599973 of Chromosome 10 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 80600773. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving exon 2 flanked by loxP sites.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations