Dennd1b^tm1.2Achn

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Species

Mus musculus

Symbol

Dennd1b^tm1.2Achn

Category

allele

Allele of gene

Dennd1b

Transgenic Constructs

None

Synonyms

None

Description

Recombination of loxP sites that flanked exon 6 resulted in the deletion of these sequences in the germline. Deletion of exon 6 results in a loss of function of the gene by generating a frameshift from exon 5 to exons 7 - 10 with the introduction of a premature stop codon in exon 7. Western blot and qRT-PCR experiments confirmed the absence of expression from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations