Allele/Variant

Tg(Plp1-Eif2ak3*)18Pop

Species
Mus musculus
Symbol
Tg(Plp1-Eif2ak3*)18Pop
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • PLP/Fv2E-PERK
Description
This transgene consists of 2.4 kb of the 5' flanking DNA, exon 1, and intron 1 of the mouse proteolipid protein driving oligodendrocyte-specific expression of the Eif2alpha kinase effector domain of Eif2ak3 fused to a polypeptide containing two modified FK506 binding domains. The activity of the kinase is dependent on the FK506 dimerizing agent AP20187. RT-PCR and Western blot confirmed the expression of mRNA and protein in the CNS and oligodendrocytes, respectively. Seven lines were established.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
  • Eif2ak3
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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