Version: 8.0.0
Date: Tue Jan 28 2025
Lacc1em3Arkr
MGI:6118041
Allele of Lacc1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Lacc1em3Arkr

Species
Mus musculus
Symbol
Lacc1em3Arkr
Category
allele
Allele of gene
Lacc1
Transgenic Constructs
None
Synonyms
  • line 9
  • mFaminp284R
Description
CRISPR guides introduced a TGT to CGT nucleotide substitutions in exon 5 that results in the amino acid substitution of arginine for cysteine at positione 284 (C284R). This allele mimics the human 'risk' variant for juvenile idiopathic arthritis and early-onset Crohn's disease.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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