Cabp2^{tm1b(KOMP)Mbp}

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Species

Mus musculus

Symbol

Cabp2^{tm1b(KOMP)Mbp}

Category

allele

Allele of gene

Cabp2

Transgenic Constructs

None

Synonyms

None

Description

The L1L2_Bact_P cassette was inserted at position 4134472 of Chromosome 19 upstream of exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4 at position 4135876. Exons 3 and 4 are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exons. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations