Sis^em1(IMPC)J

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Species

Mus musculus

Symbol

Sis^em1(IMPC)J

Category

allele

Allele of gene

Sis

Transgenic Constructs

None

Synonyms

• Sis-KO

Description

This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GCCAACTTAGAACATGTATT, CATGTATTGGGCTATCATGG, ATAGCTATCAAGTTCAGGTG and GCCCTAGTCATTGCTACAAA, which resulted in a 366 bp deletion beginning at Chromosome 3 position 72,960,985 bp and ending after 72,961,350 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000496008 (exon 4) and 248 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 75 and early truncation 5 amino acids later.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations