Cabyr^em1Osb

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Species

Mus musculus

Symbol

Cabyr^em1Osb

Category

allele

Allele of gene

Cabyr

Transgenic Constructs

None

Synonyms

• Cabyr-KO
• Cabyr⁺¹⁷

Show All 3

Description

Exon 2, which contains the ATG translation start codon and is shared amongst all known splice variants, was targeted using an sgRNA and CRISPR/Cas9. The resulting allele has a 17 bp insertion in exon 2, resulting in a reading frame shift and subsequent premature stop codon in exon 3. Immunoblots of extracts from spermatozoa demonstrate the lack of protein expression from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations