Allele/Variant

Cabyrem1Osb

Species
Mus musculus
Symbol
Cabyrem1Osb
Category
allele
Allele of gene
Cabyr
Transgenic Constructs
None
Synonyms
  • Cabyr-KO
  • Cabyr+17
Description
Exon 2, which contains the ATG translation start codon and is shared amongst all known splice variants, was targeted using an sgRNA and CRISPR/Cas9. The resulting allele has a 17 bp insertion in exon 2, resulting in a reading frame shift and subsequent premature stop codon in exon 3. Immunoblots of extracts from spermatozoa demonstrate the lack of protein expression from this allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations