Scn4b^tm1.2Geh

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Species

Mus musculus

Symbol

Scn4b^tm1.2Geh

Category

allele

Allele of gene

Scn4b

Transgenic Constructs

None

Synonyms

• Scn4b KO

Description

A targeting vector was designed to insert a loxP site, followed by a FRT-flanked neomycin resistance (neo) cassette, upstream of exon 2, and a second loxP site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. Cre-mediated recombination removed exon 2, which is predicted to cause a frameshift mutation resulting in a truncated product. Western blot analysis confirmed the absence of the 37 kD protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations